Introduction
Sample preparation is the foundation of any reliable laboratory analysis. No matter how advanced your instruments or methods are, inaccurate or contaminated samples will always lead to compromised results. This article highlights the five most common mistakes researchers and lab professionals make during sample prep—and how to avoid them.
1. Using Improper Containers or Tools
Many errors start with using the wrong type of vial, pipette tip, or storage tube. Some materials may react with your sample or introduce contamination.
Avoid it by:
- Using certified, inert, and sterile consumables
- Ensuring compatibility with your test method (e.g., glass vs. plastic)
2. Cross-Contamination Between Samples
Cross-contamination can occur due to unclean instruments, improper labeling, or shared workspaces.
Avoid it by:
- Using disposable gloves and pipette tips
- Cleaning workstations between samples
- Labeling samples clearly and securely
3. Inconsistent Sample Volume or Weight
Variability in sample quantity can lead to inaccurate comparisons and inconsistent results.
Avoid it by:
- Using calibrated equipment (balances, pipettes)
- Establishing SOPs for sample measurement
- Recording exact quantities in lab notes
4. Poor Storage or Transport Conditions
Improper temperature, exposure to light, or delays in transport can degrade sensitive samples.
Avoid it by:
- Using temperature-controlled containers when needed
- Minimizing sample handling time
- Following appropriate preservation protocols
5. Skipping Homogenization or Mixing
Uneven samples lead to unreliable test results. This is especially common with soil, water, and food matrices.
Avoid it by:
- Mixing thoroughly before subsampling
- Using standard homogenization methods
- Documenting your prep method in reports
Conclusion
Clean, consistent, and careful sample preparation saves time, prevents rework, and ensures accurate results. By identifying and avoiding these common mistakes, your lab can maintain high standards and produce data you can trust.
✅ Need Help With Your Sample Prep SOPs?
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